The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2007
Filed:
Mar. 01, 2007
Rainer Mueller, Penzberg, DE;
Johann-peter Thalhofer, Weilheim, DE;
Frank Geipel, Penzberg, DE;
Werner Hoelke, Penzberg, DE;
Thomas Kirschbaum, Munich, DE;
Rainer Mueller, Penzberg, DE;
Johann-Peter Thalhofer, Weilheim, DE;
Frank Geipel, Penzberg, DE;
Werner Hoelke, Penzberg, DE;
Thomas Kirschbaum, Munich, DE;
Roche Diagnostics Operations, Inc., Indianapolis, IN (US);
Abstract
The invention concerns a method for the recombinant production or expression of eukaryotic alkaline phosphatase mutants in yeast cells wherein the specifically introduced mutations result in a reduction of the specific AP activity by at least a factor 1:100. The invention also concerns a method for inserting corresponding nucleic acid sequences into a vector for expression in methylotrophic yeast strains and it concerns corresponding vectors and host strains.