Location History:
- Gaithersburg, MD (US) (1996 - 1998)
- Potomac, MD (US) (1998 - 2001)
- Falls Church, VA (US) (2000 - 2002)
- Bethesda, MD (US) (1998 - 2003)
- Germantown, MD (US) (2003 - 2006)
Company Filing History:
18 out of 88 
3 out of 1,521 
1 out of 832,680 Years Active: 1996-2006
Title: Thomas J Wickham: Innovator in Viral Vector Libraries
Introduction
Thomas J Wickham, a prominent inventor based in Germantown, MD, has made significant contributions to the field of biotechnology. With a remarkable portfolio of 19 patents, Wickham has focused his research on viral vector libraries and gene transfer methods, paving the way for advancements in gene therapy and related applications.
Latest Patents
Wickham's most recent patents revolve around innovative methods in the preparation and utilization of viral vector libraries. One of his notable inventions outlines a library of viral vectors, each containing a first heterologous DNA that encodes a first gene product, along with a second heterologous DNA that varies among members of the library. This innovative method of constructing viral vector libraries involves homologous recombination, enabling the creation of diverse viral vector genomes essential for various therapeutic applications.
Another significant patent details the development of a recombinant adenovirus. This invention features coat proteins that lack native binding, specifically focusing on a penton base protein and a fiber protein that are designed to enhance cellular targeting. By incorporating a nonnative amino acid sequence for binding to cell-surface receptors, this adenovirus holds potential for more effective gene delivery systems.
Career Highlights
Throughout his illustrious career, Wickham has been associated with reputable organizations including Genvec, Inc. and Cornell Research Foundation Inc. His work in these institutions has contributed to an enriched understanding of viral vectors and their applications in gene therapy, broadening the scope for medical advancements.
Collaborations
Wickham has collaborated with esteemed colleagues such as Imre Kovesdi and Petrus W Roelvink. These partnerships have played a crucial role in refining his inventions and exploring new frontiers in biotechnology.
Conclusion
In summary, Thomas J Wickham’s contributions to the field of viral vector technology underscore his status as a leading inventor in the biotechnology sector. His innovative patents not only advance scientific knowledge but also hold promise for transformative applications in medicine and therapeutics, offering hope for improved gene delivery mechanisms and treatments.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.