The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2004
Filed:
Feb. 09, 2001
Applicant:
Inventors:
Petrus W. Roelvink, Olney, MD (US);
Imre Kovesdi, Rockville, MD (US);
Thomas J. Wickham, Germantown, MD (US);
Assignee:
GenVec, Inc., Gaithersburg, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/534 ; C12N 1/563 ; C12N 1/5861 ; C07H 2/104 ; C07K 1/4075 ;
U.S. Cl.
CPC ...
C12N 1/534 ; C12N 1/563 ; C12N 1/5861 ; C07H 2/104 ; C07K 1/4075 ;
Abstract
The present invention provides a chimeric protein IX (pIX). The chimeric pIX protein has an adenoviral pIX domain and also a non-native amino acid. Where the non-native amino acid is a ligand that binds to a substrate present on the surface cells, the chimeric pIX can be used to target vectors containing such proteins to desired cell types. Thus, the invention provides vector systems including such chimeric pIX proteins as well as methods of infecting cells using such vector systems.