The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2006
Filed:
Feb. 09, 2001
Imre Kovesdi, Rockville, MD (US);
Duncan L. Mcvey, Derwood, MD (US);
Thomas J. Wickham, Germantown, MD (US);
Joseph T. Bruder, Ijamsville, MD (US);
Douglas E. Brough, Olney, MD (US);
Imre Kovesdi, Rockville, MD (US);
Duncan L. McVey, Derwood, MD (US);
Thomas J. Wickham, Germantown, MD (US);
Joseph T. Bruder, Ijamsville, MD (US);
Douglas E. Brough, Olney, MD (US);
GenVec, Inc., Gaithersburg, MD (US);
Abstract
The present invention provides a library of viral vectors, wherein each member comprises a first heterologous DNA encoding a first gene product and a second heterologous DNA encoding a second gene product. The first heterologous DNA is common to each member of the library, while the second heterologous DNA varies between members of the library. The present invention additionally provides a method of constructing a library of viral vectors. The method comprises carrying out homologous recombination between a first DNA molecule and a second DNA molecule to form a pool of intermediate viral vector genomes. One or more linear third DNA molecules are ligated into the pool of intermediate viral genomes to produce a library of viral vector genomes. Alternatively, homologous recombination between linear DNA molecules and recipient DNA molecules produces a library of viral vector genomes. The library of viral vector genomes is converted into a library of viral vectors.