The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2002
Filed:
Sep. 10, 1999
Applicant:
Inventors:
Thomas J. Wickham, Falls Church, VA (US);
Imre Kovesdi, Rockville, MD (US);
Petrus W. Roelvink, Olney, MD (US);
Joseph T. Bruder, Ijamsville, MD (US);
Assignee:
GenVec, Inc., Gaithersburg, MD (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 1/586 ; C12N 1/5861 ; C12N 1/509 ; C07H 2/104 ;
U.S. Cl.
CPC ...
C12N 1/586 ; C12N 1/5861 ; C12N 1/509 ; C07H 2/104 ;
Abstract
The present invention provides a recombinant protein having an amino terminus of an adenoviral fiber protein and having a trimerization domain. A fiber incorporating such a protein exhibits reduced affinity for a native substrate than does a wild-type adenoviral fiber trimer. The present invention further provides an adenovirus incorporating the recombinant protein of the present invention.