Location History:
- Chiba, JP (2004 - 2012)
- Kisarazu, JP (2004 - 2017)
Company Filing History:
6 out of 14 
5 out of 950 
5 out of 11 
Years Active: 2004-2017
Title: Takahiro Nagase: Innovating Antibody Solutions
Introduction
Takahiro Nagase is a notable inventor based in Chiba, Japan, known for his significant contributions in the field of antibody research. With an impressive portfolio of 14 patents, Nagase has made strides in advancing our understanding and development of monoclonal antibodies, particularly those targeting dog immunoglobulin E (IgE).
Latest Patents
One of his latest innovations is the development of the anti-dog IgE monoclonal antibody. The aim of this invention is to provide a polynucleotide encoding both the light-chain and heavy-chain variable regions of the anti-dog IgE antibody. The solution involves DNA sequences that encode a heavy-chain variable region, as represented by amino acid sequences SEQ ID NO: 2 or 6, and a light-chain variable region indicated by SEQ ID NO: 4 or 8. This invention not only advances the field of immunology but also enhances therapeutic options for conditions associated with dog allergies.
Another significant patent revolves around an antibody to a guanine nucleotide exchange factor (GEF). This invention discloses a gene encoding a novel protein that acts as a GEF for Rho family proteins. This patent also encompasses methods for identifying compounds that inhibit the protein's function, methods for determining related diseases, and the creation of pharmaceutical compositions and reagent kits.
Career Highlights
Throughout his career, Takahiro Nagase has been associated with renowned research institutions and pharmaceutical companies. He has worked at Kazusa DNA Research Institute, where he likely refined his skills and expertise in genetic analysis. Additionally, his role at Chugai Seiyaku Co., Ltd., a leading Japanese pharmaceutical company, has further solidified his reputation in the field of biopharmaceuticals.
Collaborations
Nagase's work has benefited from collaborative efforts with prominent scientists, including Osamu Ohara and Shin-Ichi Funahashi. These partnerships have fostered an environment of innovation, leading to breakthroughs in antibody development and applications in medical research.
Conclusion
Takahiro Nagase continues to be a driving force in the world of antibody research and innovation. His patents not only demonstrate his technical expertise but also address significant medical challenges related to allergies and protein interactions. As an inventor, his work contributes to the advancement of biomedical sciences, paving the way for new therapeutic solutions.