The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2011
Filed:
Oct. 26, 2006
Naoyuki Inagaki, Ikoma, JP;
Tatsuya Mori, Wako, JP;
Osamu Ohara, Kisarazu, JP;
Takahiro Nagase, Kisarazu, JP;
Naoyuki Inagaki, Ikoma, JP;
Tatsuya Mori, Wako, JP;
Osamu Ohara, Kisarazu, JP;
Takahiro Nagase, Kisarazu, JP;
National University Corporation Nara Institute of Science and Technology, Ikoma-shi, JP;
Kazusa DNA Research Institute, Kisarazu-shi, JP;
Abstract
Singar is identified as a novel molecule, whose expression is varied before and after the polarization of a nerve cell, and occurs in the tip of an elongating axon, called a growth cone, which is important for the formation or elongation of an axon. Singar is expressed specifically in the brain and the amount of Singar expression is largely increased in an individual during periods where the formation of axons is increased. It is observed that Singar is highly enriched in the growth cone at the tip of an axon. When the expression of Singar is inhibited in nerve cells in culture, the formation of multiple axons is induced. Thus, the inhibition of Singar can induce axon formation. Therefore, by inhibiting the expression or activity of Singar, it becomes possible to induce or promote the formation or elongation of an axon in a nerve cell.