This inventor holds 35 USPTO granted patents and 7 published patent applications and 27 EPO patents, primarily in Meningococcal Vaccines. Top assignees: Glaxosmithkline Biologicals Sa, Novartis Ag, Chiron Corporation. Active years: 2001-2026.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Location History:
- Colle d'Elsa, IT (2002)
- Colle Val Dielsa, IT (2014)
- Monteriggioni, IT (2018 - 2020)
- Colle Val D'Elsa, IT (2001 - 2021)
- Siena, IT (2011 - 2021)
Company Filing History:
24 out of 545 
9 out of 3,978 
2 out of 672 
Years Active: 2001-2026
Areas of Expertise:
Title: Paolo Costantino: Innovator in Capsular Polysaccharide Technology
Introduction
Paolo Costantino, a prominent inventor based in Siena, Italy, has made significant contributions to the field of biotechnology with a particular focus on capsular polysaccharides. With an impressive portfolio of 34 patents, his innovations continue to advance the science of microbial product purification and therapeutic applications.
Latest Patents
Costantino's latest inventions center around type 5 capsular saccharides. One notable patent outlines a method for releasing capsular polysaccharide from type 5 or type 8 cells. This process involves treating the cells with acid and includes additional purification steps such as enzymatic treatment to remove nucleic acid, protein, and peptidoglycan contaminants. The method also incorporates diafiltration and anion exchange chromatography to ensure high purity and concentration of the end products. Furthermore, his purification method for a GAS carbohydrate employs anionic exchange chromatography, yielding high-quality saccharides with minimal contamination from hyaluronic acid, protein, and nucleic acids.
Career Highlights
Throughout his career, Paolo Costantino has been associated with leading pharmaceutical companies, including GlaxoSmithKline Biologicals and Novartis AG. His work in these organizations has placed him at the forefront of research and development in biopharmaceutical innovations, particularly in the area of polysaccharide extraction and purification. His extensive patent portfolio underscores his role as an influential inventor in the field.
Collaborations
Costantino has collaborated with various talented individuals throughout his career, including Francesco Berti and Maria Rosaria Romano. These partnerships have contributed to the successful development and commercialization of his innovative technologies.
Conclusion
Paolo Costantino's contributions to the field of biotechnology reflect his dedication to advancing scientific understanding and practical applications of capsular polysaccharides. With 34 patents to his name, his work stands as a testament to the impact of innovation in health sciences and pharmaceutical developments.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile