The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2017
Filed:
Jan. 20, 2009
Applicant:
Paolo Costantino, Siena, IT;
Inventor:
Paolo Costantino, Siena, IT;
Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/385 (2006.01); A61K 45/00 (2006.01); A61K 47/00 (2006.01); A61K 39/00 (2006.01); A61K 39/095 (2006.01); A61K 39/102 (2006.01); A61K 39/09 (2006.01); A61K 39/08 (2006.01); C09F 1/02 (2006.01); A23J 1/00 (2006.01); C07K 1/00 (2006.01); C07K 14/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); C07K 1/06 (2006.01); C07K 1/08 (2006.01); C09G 1/00 (2006.01); A23J 1/04 (2006.01); A61K 38/00 (2006.01); A23J 1/20 (2006.01); C07H 15/04 (2006.01); C07K 14/22 (2006.01); C07K 14/285 (2006.01); A61K 38/48 (2006.01); A61K 39/39 (2006.01);
U.S. Cl.
CPC ...
A61K 39/095 (2013.01); A23J 1/04 (2013.01); A23J 1/205 (2013.01); A61K 38/00 (2013.01); A61K 38/4893 (2013.01); A61K 39/092 (2013.01); A61K 39/102 (2013.01); A61K 39/39 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/6037 (2013.01); C07H 15/04 (2013.01); C07K 14/22 (2013.01); C07K 14/285 (2013.01); C09G 1/00 (2013.01); Y10S 424/831 (2013.01);
Abstract
Precipitated bacterial capsular polysaccharides can be efficiently re-solubilized using alcohols as solvents. The invention provides a process for purifying a bacterial capsular polysaccharide, comprising the steps of (a) precipitation of said polysaccharide, followed by (b) solubilization of the precipitated polysaccharide using ethanol. CTAB can be used for step (a). The material obtained, preferably following hydrolysis and sizing, can be conjugated to a carrier protein and formulated as a vaccine. Also, in vaccines comprising saccharides from both serogroups A and C, the invention provides that the ratio (w/w) of MenA saccharide:MenC saccharide is >1.