The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10716841 B1

PDF
Full Text
Expired
Date of Patent:
Jul. 21, 2020

Filed:

Oct. 31, 2016
Applicant:

Glaxosmithkline Biologicals SA, Rixensart, BE;

Inventor:

Paolo Costantino, Siena, IT;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/095 (2006.01); A61K 45/00 (2006.01); A61K 47/00 (2006.01); A61K 39/00 (2006.01); C09F 1/00 (2006.01); A23J 1/04 (2006.01); A61K 38/00 (2006.01); A23J 1/20 (2006.01); C07H 15/04 (2006.01); A61K 39/09 (2006.01); C07K 14/22 (2006.01); C07K 14/285 (2006.01); A61K 38/48 (2006.01); A61K 39/102 (2006.01); A61K 39/39 (2006.01); C09G 1/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/095 (2013.01); A23J 1/04 (2013.01); A23J 1/205 (2013.01); A61K 38/00 (2013.01); A61K 38/4893 (2013.01); A61K 39/092 (2013.01); A61K 39/102 (2013.01); A61K 39/39 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/6037 (2013.01); C07H 15/04 (2013.01); C07K 14/22 (2013.01); C07K 14/285 (2013.01); C09F 1/00 (2013.01); C09G 1/00 (2013.01); Y02A 50/466 (2018.01); Y10S 424/831 (2013.01);
Abstract

Precipitated bacterial capsular polysaccharides can be efficiently re-solubilised using alcohols as solvents. The invention provides a process for purifying a bacterial capsular polysaccharide, comprising the steps of (a) precipitation of said polysaccharide, followed by (b) solubilisation of the precipitated polysaccharide using ethanol. CTAB can be used for step (a). The material obtained, preferably following hydrolysis and sizing, can be conjugated to a carrier protein and formulated as a vaccine. Also, in vaccines comprising saccharides from both serogroups A and C, the invention provides that the ratio (w/w) of Men A saccharide:MenC saccharide is >1.


Find Patent Forward Citations

Costantino, Paolo. (2020). Capsular polysaccharide solubilisation and combination vaccines (U.S. Patent No. 10716841). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10716841

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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