The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 2021
Filed:
Feb. 13, 2019
Glaxosmithkline Biologicals, S.a., Rixensart, BE;
Paolo Costantino, Colle Val d'Elsa, IT;
Maria Rosaria Romano, Pontedera, IT;
Francesco Berti, Colle Val d'Elsa, IT;
GLAXOSMITHKLINE BIOLOGICALS SA, Rixensart, BE;
Abstract
The invention provides a method for releasing capsular polysaccharide fromtype 5 or type 8 cells, comprising the step of treating the cells with acid. The invention further provides a process for purifying capsular polysaccharide fromtype 5 or type 8 cells comprising this method. Other processing steps may be included in the process, such as enzymatic treatment, e.g. to remove nucleic acid, protein and/or peptidoglycan contaminants; diafiltration, e.g. to remove low molecular weight contaminants; anion exchange chromatography, e.g. to remove residual protein; and concentration. The invention also provides a composition comprising atype 5 or type 8 capsular polysaccharide, obtainable by any of the processes of the invention.