This inventor holds 8 USPTO granted patents and 9 published patent applications and 3 EPO patents. Top assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc., Merck Sharp + Dohme Corp., The Wistar Institute. Active years: 2009-2022.
Location History:
- Yeadon, PA (US) (2009 - 2020)
- Colmar, PA (US) (2022)
Company Filing History:
3 out of 311 
3 out of 2,405 
2 out of 246 
Years Active: 2009-2022
Title: Michael V Nebozhyn: Innovator in Gene Signature Biomarkers
Introduction
Michael V Nebozhyn is a prominent inventor based in Yeadon, Pennsylvania, known for his significant contributions to the field of gene signature biomarkers. With a total of eight patents to his name, he has made remarkable strides in understanding tumor responses to PD-1 antagonists.
Latest Patents
Among his latest patents, Nebozhyn has developed a system and methods for deriving gene signature biomarkers of response to PD-1 antagonists. This gene expression platform combines a set of genes correlated with responses to PD-1 antagonists across multiple tumor types, along with a normalization gene set. The patent also includes methods for using this platform to derive predictive gene signature biomarkers from patient samples. Another notable patent focuses on blood-based biomarkers of tumor sensitivity to PD-1 antagonists. This disclosure outlines baseline and on-treatment blood-based gene signature biomarkers that predict tumor sensitivity to therapy with PD-1 antagonists. The on-treatment biomarkers include a PD-L1 gene signature or an interferon gamma gene signature, while the baseline gene signature comprises genes associated with the oxidative phosphorylation pathway. Additionally, the patent provides methods and kits for testing tumor samples for these biomarkers and outlines treatment methods based on test results.
Career Highlights
Throughout his career, Michael V Nebozhyn has worked with esteemed organizations such as the H. Lee Moffitt Cancer Center and Research Institute, Inc. and Merck Sharp & Dohme Corporation. His work has significantly impacted cancer research and treatment methodologies.
Collaborations
Some of his notable coworkers include Andrey Loboda and James J Mulé, who have collaborated with him on various projects in the field of cancer research.
Conclusion
Michael V Nebozhyn's innovative work in gene signature biomarkers has paved the way for advancements in cancer treatment and patient care. His contributions continue to influence the field and offer hope for improved therapeutic strategies.