The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2022
Filed:
Dec. 08, 2015
Mark D. Ayers, Pennington, NJ (US);
Andrey Loboda, Canton, MA (US);
Jared K. Lunceford, Washington, UT (US);
Terrill K. Mcclanahan, Sunnyvale, CA (US);
Erin E. Murphy, Redwood City, CA (US);
Michael Nebozhyn, Colmar, PA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Mark D. Ayers, Pennington, NJ (US);
Andrey Loboda, Canton, MA (US);
Jared K. Lunceford, Washington, UT (US);
Terrill K. McClanahan, Sunnyvale, CA (US);
Erin E. Murphy, Redwood City, CA (US);
Michael Nebozhyn, Colmar, PA (US);
Merck Sharp & Dohme LLC, Rahway, NJ (US);
Abstract
A gene expression platform, which is a combination of a set of genes that are correlated with response to a PD-1 antagonist in multiple tumor types and a normalization gene set, is disclosed. A method and system of using the gene expression platform to derive gene signature biomarkers of anti-tumor response to a PD-1 antagonist and to test patient samples for predictive gene signature biomarkers are also disclosed.