The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2022
Filed:
Apr. 12, 2016
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Mark Ayers, Pennington, NJ (US);
Jared Lunceford, Washington, UT (US);
Andrey Loboda, Boston, MA (US);
Michael Nebozhyn, Colmar, PA (US);
Terrill K. McClanahan, Sunnyvale, CA (US);
Heather Hirsch, Brookline, MA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present disclosure describes baseline and on treatment blood-based gene signature biomarkers that are predictive of tumor sensitivity to therapy with a PD-1 antagonist. The on-treatment biomarkers comprise a PD-L1 gene signature or an interferon gamma gene signature and the baseline gene signature biomarker comprises genes associated with the oxidative phosphorylation pathway. The disclosure also provides methods and kits for testing tumor samples for these biomarkers, as well as methods for treating subjects with a PD-1 antagonist based on the test results.