The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2009
Filed:
May. 21, 2004
Louise C. Showe, Media, PA (US);
Michael K. Showe, Media, PA (US);
Laszlo Kari, Hamilton, MT (US);
Michael Nebozhyn, Yeadon, PA (US);
Andrey Loboda, Philadelphia, PA (US);
Louise C. Showe, Media, PA (US);
Michael K. Showe, Media, PA (US);
Laszlo Kari, Hamilton, MT (US);
Michael Nebozhyn, Yeadon, PA (US);
Andrey Loboda, Philadelphia, PA (US);
The Wistar Institute of Anatomy & Biology, Philadelphia, PA (US);
Abstract
A method of developing a gene expression profile indicative of the presence or stage of a selected a disease, disorder or genetic pathology in a mammalian subject employs penalized discriminant analysis with recursive feature elimination. A method of diagnosing a cancer in a mammalian subject includes the steps of examining a sample containing the subject's immune cells and detecting a variance in the expression of a statistically significant number of genes, e.g., at least 10 non-tumor genes from those same genes in a characteristic disease or healthy gene expression profile. A significant variance in expression of these genes when compared to a gene expression profile, preferably an average gene expression profile of a normal control, or significant similarities to an average gene profile of subjects with cancer, correlates with a specific type of cancer and/or location of tumor.