Michael H Shapero

Title: Innovations and Contributions of Michael H. Shapero

Introduction

Michael H. Shapero is a prominent inventor based in Redwood City, California, known for his significant contributions to the field of molecular biology and genetic analysis. With an impressive portfolio of 26 patents, he has made substantial advancements in technologies related to genotyping, sequencing, and the analysis of nucleic acid samples.

Latest Patents

Among his latest innovations, Shapero has developed techniques for locus-specific amplification using array probes. This method provides multiplexed amplification of selected targets, allowing for both amplification and analysis to occur on the same solid support. The analysis focuses on determining the sequence at various locations within the amplified target, enhancing applications in genotyping, sequencing, and copy number analysis.

Another noteworthy patent involves array-based methods for analyzing mixed samples with differently labeled allele-specific probes. This disclosure outlines methods and systems for multiplex genotyping of mixed nucleic acid populations. It highlights the detection of differences in copy number of target polynucleotides, including important applications such as prenatal testing and cancer diagnostics. These methods utilize molecular inversion probes to hybridize amplified fragments to an oligonucleotide array and determine allele ratios, thus providing insights into fetal and maternal copy number variations.

Career Highlights

Michael H. Shapero has held significant positions at leading companies in the biotechnology sector, including Affymetrix, Inc. and Dendreon Corporation. His work in these organizations has been crucial in pushing forward the boundaries of genetic research and commercial applications.

Collaborations

Throughout his career, Shapero has collaborated with esteemed professionals in the field, including Keith W. Jones and Glenn K. Fu. Their collective efforts have contributed to groundbreaking developments that have notable implications in molecular diagnostics and therapeutic approaches.

Conclusion

Michael H. Shapero's innovative work continues to have a lasting impact on the fields of genetics and molecular biology. His patents exemplify the intersection of science and technology, and they pave the way for future advancements in diagnostics and treatments for various genetic conditions. As a prolific inventor, Shapero's contributions remain pivotal in enhancing our understanding and manipulation of genetic materials.