The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 23, 2018

Filed:

Apr. 30, 2012
Applicants:

Jing Huang, Sunnyvale, CA (US);

Keith W. Jones, Sunnyvale, CA (US);

Michael H. Shapero, Sunnyvale, CA (US);

Inventors:

Jing Huang, Sunnyvale, CA (US);

Keith W. Jones, Sunnyvale, CA (US);

Michael H. Shapero, Sunnyvale, CA (US);

Assignee:

Affymetrix, Inc., Carlsbad, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G06F 19/00 (2018.01); G06F 19/18 (2011.01); C12Q 1/6827 (2018.01); C12Q 1/6837 (2018.01); G06F 19/20 (2011.01);
U.S. Cl.
CPC ...
G06F 19/18 (2013.01); C12Q 1/6827 (2013.01); C12Q 1/6837 (2013.01); G06F 19/20 (2013.01);
Abstract

Methods of identifying allele-specific changes in genomic DNA copy number are disclosed. Methods for identifying homozygous deletions and genetic amplifications are disclosed. An array of probes designed to detect presence or absence of a plurality of different sequences is also disclosed. The probes are designed to hybridize to sequences that are predicted to be present in a reduced complexity sample. The methods may be used to detect copy number changes in cancerous tissue compared to normal tissue. The methods may be used to diagnose cancer and other diseases associated with chromosomal anomalies.


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