Keith W Jones

Title: Innovations and Achievements of Keith W. Jones

Introduction

Keith W. Jones, based in Sunnyvale, California, is an accomplished inventor with an impressive portfolio of 31 patents. His work primarily focuses on advancements in the field of genetic analysis and diagnostics, showcasing his expertise in the application of enzymatic methods and innovative technologies.

Latest Patents

Among his latest patents, two notable inventions stand out. The first is titled "Enzymatic methods for genotyping on arrays," which encompasses methods for enzymatically identifying polymorphisms on solid supports. This invention includes techniques such as ligation of allele or base-specific 5' interrogation probes to an array probe, where the labeling of the array probe is contingent upon the identity of the base adjacent to the array probe's end. In some aspects, labeled probes bound to the array are achieved via template-dependent extension.

The second significant patent, "Using cell-free DNA fragment size to determine copy number variations," introduces methods for determining copy number variations (CNV) that are potentially linked to various medical conditions. This innovation presents approaches to assess CNVs associated with fetuses by utilizing maternal samples containing both maternal and fetal cell-free DNA. The methodology aims to enhance the sensitivity and specificity of sequence data analysis by employing fragment size parameters, employing t-statistics for evaluation, and combining fetal fraction estimates with statistical methods.

Career Highlights

Throughout his career, Keith has contributed his expertise to renowned companies such as Affymetrix, Inc. His work in these firms underscores his commitment to advancing genetic technology and improving diagnostic methods in biotechnology contexts.

Collaborations

Keith W. Jones has collaborated with esteemed professionals in the industry, including Michael H. Shapero and Jing Huang. These partnerships reflect the collaborative nature of innovation within the field and highlight the synergistic efforts of talented individuals working towards common goals.

Conclusion

In conclusion, Keith W. Jones stands as a prominent figure in the realm of genetics and biotechnology, with numerous patents that have the potential to significantly impact medical diagnostics. His inventive contributions and collaborations with other experts mark him as a key player in driving innovation forward in the scientific community.