Company Filing History:
12 out of 12 
5 out of 2,007 
3 out of 3 Years Active: 1991-2018
Title: L David Williams: Innovator in Bioconjugate Chemistry
Introduction
L David Williams is a prominent inventor based in Fremont, CA, known for his significant contributions to bioconjugate chemistry. With a total of 18 patents to his name, he has made remarkable advancements in the field of enzyme modification and therapeutic applications.
Latest Patents
Among his latest patents, Williams has developed PEG-urate oxidase conjugates and their applications. This invention involves a naturally occurring or recombinant urate oxidase covalently coupled to poly(ethylene glycol) (PEG), where an average of 2 to 10 strands of PEG are conjugated to each uricase subunit. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme. Another notable patent is related to polymer conjugates of interferon-beta with enhanced biological potency. This invention provides methods for synthesizing polymer conjugates of cytokines, particularly a non-glycosylated interferon-beta, which retain unusually high biological potency. These conjugates exhibit an extended half-life in vivo compared to their unconjugated counterparts, making them valuable for therapeutic applications, including the treatment of multiple sclerosis.
Career Highlights
Throughout his career, Williams has worked with various organizations, including Mountain View Pharmaceuticals and Duke University. His work has focused on enhancing the efficacy and safety of therapeutic proteins through innovative bioconjugation techniques.
Collaborations
Williams has collaborated with notable colleagues such as Mark G P Saifer and Merry R Sherman, contributing to the advancement of bioconjugate research and its applications in medicine.
Conclusion
L David Williams stands out as a key figure in the field of bioconjugate chemistry, with a strong portfolio of patents that reflect his innovative spirit and dedication to improving therapeutic solutions. His work continues to influence the development of advanced medical treatments.
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