The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2011
Filed:
Apr. 28, 2010
L. David Williams, Fremont, CA (US);
Michael S. Hershfield, Durham, NC (US);
Susan J. Kelly, Chapel Hill, NC (US);
Mark G. P. Saifer, San Carlos, CA (US);
Merry R. Sherman, San Carlos, CA (US);
L. David Williams, Fremont, CA (US);
Michael S. Hershfield, Durham, NC (US);
Susan J. Kelly, Chapel Hill, NC (US);
Mark G. P. Saifer, San Carlos, CA (US);
Merry R. Sherman, San Carlos, CA (US);
Mountain View Pharmaceuticals, Inc., Menlo Park, CA (US);
Duke University, Durham, NC (US);
Abstract
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.