The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2011
Filed:
Aug. 03, 2007
Merry R. Sherman, San Carlos, CA (US);
Mark G. P. Saifer, San Carlos, CA (US);
L. David Williams, Fremont, CA (US);
Michael S. Hershfield, Durham, NC (US);
Susan J. Kelly, Chapel Hill, NC (US);
Merry R. Sherman, San Carlos, CA (US);
Mark G. P. Saifer, San Carlos, CA (US);
L. David Williams, Fremont, CA (US);
Michael S. Hershfield, Durham, NC (US);
Susan J. Kelly, Chapel Hill, NC (US);
Mountain View Pharmaceuticals, Inc., Menlo Park, CA (US);
Abstract
A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.