Kirk Ekena

Title: Kirk Ekena: Innovator in Polymer Technology

Introduction

Kirk Ekena is a notable inventor based in Fitchburg, WI (US), recognized for his contributions to polymer technology. With a total of 6 patents, Ekena has made significant advancements in the field, particularly in the area of cellular delivery systems.

Latest Patents

Ekena's latest patents include innovative technologies such as reversibly masked polymers and endosomolytic polymers. The reversibly masked polymers invention focuses on creating membrane-active polymers that facilitate the cellular delivery of compounds. These polyconjugate systems are designed to incorporate various functionalities, including targeting, anti-opsonization, anti-aggregation, and transfection activities, into small biocompatible delivery conjugates. The use of multiple reversible linkages allows for modulation of activity in response to physiological conditions. His endosomolytic polymers are pH-sensitive and capable of delivering polynucleotides to cells from the peripheral circulation, releasing them from endosomes. These polymers remain inactive outside the cell but disrupt membranes when exposed to an acidified endosomal environment.

Career Highlights

Throughout his career, Ekena has worked with prominent companies such as Mirus Bio Corporation and Roche Madison Inc. His experience in these organizations has contributed to his expertise in polymer science and technology.

Collaborations

Ekena has collaborated with notable individuals in his field, including David B Rozema and Jon Asher Wolff. These partnerships have likely enhanced his research and development efforts.

Conclusion

Kirk Ekena's innovative work in polymer technology has led to significant advancements in cellular delivery systems, showcasing his expertise and commitment to scientific progress. His contributions continue to impact the field positively.