The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2018
Filed:
Jan. 12, 2015
Applicant:
Arrowhead Madison Inc., Madison, WI (US);
Inventors:
David B Rozema, Middleton, WI (US);
Jon A Wolff, Madison, WI (US);
James E Hagstrom, Middleton, WI (US);
Kirk Ekena, Fitchburg, WI (US);
Assignee:
Arrowhead Pharmaceuticals, Inc., Pasadena, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); C07H 21/02 (2006.01); A61K 9/14 (2006.01); A61K 47/32 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); C12N 15/87 (2006.01); A61K 47/60 (2017.01); A61K 47/58 (2017.01);
U.S. Cl.
CPC ...
A61K 48/0041 (2013.01); A61K 47/58 (2017.08); A61K 47/60 (2017.08); C12N 15/87 (2013.01); A01K 2217/058 (2013.01); A01K 2267/0362 (2013.01);
Abstract
The present invention is directed to reversibly inactivated membrane active polymers useful for cellular delivery of compounds. Described are polyconjugate systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.