The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2012
Filed:
Sep. 19, 2006
David B. Rozema, Middleton, WI (US);
Darren H. Wakefield, Fitchburg, WI (US);
Jon A. Wolff, Madison, WI (US);
James E. Hagstrom, Middleton, WI (US);
Kirk Ekena, Fitchburg, WI (US);
David B. Rozema, Middleton, WI (US);
Darren H. Wakefield, Fitchburg, WI (US);
Jon A. Wolff, Madison, WI (US);
James E. Hagstrom, Middleton, WI (US);
Kirk Ekena, Fitchburg, WI (US);
Arrowhead Madison Inc., Madison, WI (US);
Abstract
We describe pH-sensitive endosomolytic polymers, delivery particles containing pH-sensitive endosomolytic polymers. The described particles are capable of delivering polynucleotides to cells from the peripheral circulation with subsequent release from endosomes. The endosomolytic polymers are inactive outside the cell but disrupt membranes upon exposure to an acidified endosomal compartment.