Location History:
- Ibaraki, JP (1993 - 2012)
- Tsukuba, JP (2008 - 2012)
Company Filing History:
8 out of 527 
7 out of 677 
1 out of 1,711 
Years Active: 1993-2012
Title: Kappei Tsukahara: Innovator in Antifungal and Antimalarial Research
Introduction
Kappei Tsukahara is a prominent inventor based in Tsukuba, Japan. He has made significant contributions to the fields of antifungal and antimalarial research, holding a total of 15 patents. His work focuses on innovative methods for screening compounds that can inhibit specific enzymatic activities related to disease-causing organisms.
Latest Patents
One of his latest patents is a method for screening compounds that inhibit the enzymatic activity of the GWT1 gene product. This invention allows for the identification of compounds that can hinder the transport of GPI-anchored proteins to fungal cell walls. The method utilizes a straightforward assay for transacylation to GlcN-PI using membrane fractions expressing the GWT1 protein. This innovation has the potential to lead to the development of new antifungal agents that can disrupt fungal cell wall synthesis and prevent adhesion to host cells.
Another significant patent involves methods for screening compounds that inhibit the biosynthesis of GPI in malaria parasites. Tsukahara and his team successfully isolated GWT1 (PfGWT1), an enzyme crucial for GPI biosynthesis in malaria parasites. They discovered that degenerate mutant DNAs, which have a lower AT content than the original DNA encoding the PfGWT1 protein, can complement the phenotype of GWT1-deficient yeast. This invention provides the GWT1 protein of malaria parasites and outlines methods for screening antimalarial drugs using these degenerate mutant DNAs.
Career Highlights
Kappei Tsukahara has worked with notable companies in the pharmaceutical industry, including Eisai R&D Management Co., Ltd. and Eisai Company, Limited. His career has been marked by a commitment to advancing research in the fight against infectious diseases.
Collaborations
Throughout his career, Tsukahara has collaborated with esteemed colleagues such as Norihiro Ueda and Katsura Hata. These partnerships have contributed to the success of his research and the development of innovative solutions in his field.
Conclusion
Kappei Tsukahara is a distinguished inventor whose work in antifungal and antimalarial research has led to significant advancements in the field. His innovative patents and collaborations highlight his dedication to improving health outcomes through scientific discovery.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.