The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2011
Filed:
Dec. 17, 2007
Kappei Tsukahara, Tsukuba, JP;
Katsura Hata, Tsukuba, JP;
Koji Sagane, Tsukuba, JP;
Kazutaka Nakamoto, Tsukuba, JP;
Mamiko Tsuchiya, Ushiku, JP;
Naoaki Watanabe, Tsukuba, JP;
Fuminori Ohba, Iruma-gun, JP;
Itaru Tsukada, Ushiku, JP;
Norihiro Ueda, Tsukuba, JP;
Keigo Tanaka, Tsukuba, JP;
Junko Kai, Niihari-gun, JP;
Kappei Tsukahara, Tsukuba, JP;
Katsura Hata, Tsukuba, JP;
Koji Sagane, Tsukuba, JP;
Kazutaka Nakamoto, Tsukuba, JP;
Mamiko Tsuchiya, Ushiku, JP;
Naoaki Watanabe, Tsukuba, JP;
Fuminori Ohba, Iruma-gun, JP;
Itaru Tsukada, Ushiku, JP;
Norihiro Ueda, Tsukuba, JP;
Keigo Tanaka, Tsukuba, JP;
Junko Kai, Niihari-gun, JP;
Eisai R & D Management Co. Ltd., Tokyo, JP;
Abstract
A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, fungal genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed. These genes encode proteins participating in fungal cell wall synthesis. Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.