The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2012
Filed:
Nov. 21, 2003
Kappei Tsukahara, Tsukuba, JP;
Mamiko Tsuchiya, Ushiku, JP;
Yoshifumi Jigami, Tsukuba, JP;
Kenichi Nakayama, Tsukuba, JP;
Mariko Umemura, Tsukuba, JP;
Michiyo Okamoto, Tsukuba, JP;
Kappei Tsukahara, Tsukuba, JP;
Mamiko Tsuchiya, Ushiku, JP;
Yoshifumi Jigami, Tsukuba, JP;
Kenichi Nakayama, Tsukuba, JP;
Mariko Umemura, Tsukuba, JP;
Michiyo Okamoto, Tsukuba, JP;
National Institute of Advanced Industrial Science and Technology, Tokyo, JP;
Eisai R&D Management Co., Ltd., Tokyo, JP;
Abstract
The present invention enables screening for compounds that inhibit the transport of GPI-anchored proteins to fungal cell walls, using a simple assay for transacylation to GlcN-PI using membrane fraction expressing GWT1 protein. New antifungal agents can be created that inhibit the synthesis of fungal cell walls and also inhibit adhesion to host cells by inhibiting the transport of GPI-anchored proteins to fungal cell walls.