The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2011
Filed:
Nov. 21, 2003
Katsura Hata, Tsukuba, JP;
Kaoru Ogawa, Tsukuba, JP;
Itaru Tsukada, Ushiku, JP;
Kazutaka Nakamoto, Tsukuba, JP;
Koji Sagane, Tsukuba, JP;
Keigo Tanaka, Tsukuba, JP;
Kappei Tsukahara, Tsukuba, JP;
Toshihiro Horii, Toyonaka, JP;
Katsura Hata, Tsukuba, JP;
Kaoru Ogawa, Tsukuba, JP;
Itaru Tsukada, Ushiku, JP;
Kazutaka Nakamoto, Tsukuba, JP;
Koji Sagane, Tsukuba, JP;
Keigo Tanaka, Tsukuba, JP;
Kappei Tsukahara, Tsukuba, JP;
Toshihiro Horii, Toyonaka, JP;
Eisai R&D Management Co., Ltd., Tokyo, JP;
Abstract
The present inventors succeeded in isolating GWT1 (PfGWT1), which is one of the enzymes involved in GPI biosynthesis in the malaria parasite. In addition, the inventors revealed that degenerate mutant DNAs, with a lower AT content than the DNA encoding the PfGWT1 protein, can complement the phenotype of GWT1-deficient yeast. Based on the findings, the present invention provides the GWT1 protein of malaria parasites and the use of the protein in methods of screening for antimalarial drugs. The present invention also provides degenerate mutant DNAs encoding proteins involved in GPI biosynthesis, and which have a lower AT content than the original DNAs. The present invention also provides methods of screening for antimalarial drugs which use the degenerate mutant DNAs.