Company Filing History:
Years Active: 2014-2024
Title: The Innovations of Joseph R Dobosy
Introduction
Joseph R Dobosy is a prominent inventor based in Coralville, IA, known for his significant contributions to the field of genetic engineering. With a total of 11 patents to his name, Dobosy has made remarkable advancements in improving the efficiency of homology directed repair (HDR) and enhancing DNA sequencing techniques.
Latest Patents
One of his latest patents focuses on "Modified double-stranded donor templates." This invention describes compositions and methods aimed at improving HDR efficiency while reducing homology-independent integration after the introduction of double strand breaks using engineered nucleases. Additionally, it includes modifications to double-stranded DNA donors to enhance their potency and efficiency in HDR following double strand breaks with programmable nucleases. Another notable patent involves "RNASE H2 mutants that reduce primer dimers and off-target amplification in RHPCR-based amplicon sequencing with high-fidelity DNA polymerases." This invention pertains to hybrid RNase H2 proteins that incorporate fragments of amino acid sequences from various organisms, along with methods to improve mismatch discrimination and activity in a high-fidelity DNA polymerase buffer.
Career Highlights
Joseph R Dobosy has established a successful career at Integrated DNA Technologies, Inc., where he continues to innovate and contribute to the field of molecular biology. His work has been instrumental in advancing techniques that are crucial for genetic research and therapeutic applications.
Collaborations
Throughout his career, Dobosy has collaborated with notable colleagues, including Mark Aaron Behlke and Scott Rose. These partnerships have fostered a collaborative environment that enhances the development of groundbreaking technologies.
Conclusion
Joseph R Dobosy's contributions to genetic engineering through his innovative patents and collaborative efforts have significantly impacted the field. His work continues to pave the way for advancements in molecular biology and genetic research.
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