This inventor holds 21 USPTO granted patents and 11 published patent applications, plus 1 CIPO patent and 1 EPO patent. Top assignees: University of Notre Dame Du Lac, University of Missouri, Gas Research Institute. Active years: 1994-2025.
Location History:
- Notre Dame, IN (US) (2002 - 2012)
- Granger, IN (US) (1994 - 2021)
- South Bend, IN (US) (2021 - 2022)
Company Filing History:
18 out of 387 
2 out of 894 
1 out of 645 
Years Active: 1994-2025
Title: Hsueh-Chia Chang: Innovator in Nanotechnology and PCR Technology
Introduction
Hsueh-Chia Chang, based in Granger, Indiana, is a prolific inventor with a remarkable portfolio of 19 patents. His contributions to the field of nanotechnology and polymerase chain reaction (PCR) technologies have significantly advanced scientific methodologies and capabilities.
Latest Patents
Among his latest patents, one notable invention is the "AC electrosprayed droplets for digital and emulsion PCR." This revolutionary technology harnesses alternating current electrospray to produce micron-sized droplets in oil at a substantial throughput, outperforming the traditional flow-focusing technology by a factor of 100. The system is capable of generating up to a trillion monodispersed droplets in about one hour, with droplet sizes easily adjustable between 1 to 100 microns through voltage variations.
Another significant patent is titled "Systems and methods for separating, detecting, and quantifying a target polynucleotide." This innovation introduces a method to control molecular translocation within solid-state nanopores, resulting in a dramatic reduction in the electrophoretic velocity of molecules. This technology enhances the sensitivity and selectivity of solid-state nanopore sensors, making it feasible for applications in polynucleotide detection and sequencing.
Career Highlights
Hsueh-Chia Chang's career includes pivotal roles at esteemed institutions such as the University of Notre Dame and the Curators of the University of Missouri. His work in these settings has facilitated advancements in research and has fostered innovation in nanotechnology and molecular biology.
Collaborations
Throughout his career, Chang has collaborated with various esteemed colleagues, including Satyajyoti Senapati and Zdenek Slouka. These collaborations have played a significant role in the creation and refinement of his patented technologies, contributing to the growth of knowledge in their respective fields.
Conclusion
Hsueh-Chia Chang's impressive body of work exemplifies his dedication to innovation in nanotechnology and molecular biology. Through his patents, he has made a lasting impact, providing the scientific community with cutting-edge tools to advance research and applications in these critical fields.