Company Filing History:
Years Active: 2010-2017
Title: Holger Gruell: Innovating Drug Delivery and Imaging Technologies
Introduction
Holger Gruell is a notable inventor based in Eindhoven, Netherlands. With a total of nine patents to his name, his work significantly advances the fields of drug delivery and medical imaging technologies. His innovative approach addresses key challenges in the medical field, particularly through his latest patents that enhance the effectiveness of drug carriers and imaging agents.
Latest Patents
One of Gruell's latest patents focuses on a drug carrier providing MRI contrast enhancement. This invention describes drug carriers that are useful in magnetic resonance imaging (MRI)-guided drug release. These carriers comprise a shell that can release an enclosed biologically active agent in response to a local stimulus, such as heat, while also acting as a contrast enhancement agent for MRI based on the principle of Chemical Exchange-dependent Saturation Transfer (CEST). The design includes a cavity containing a paramagnetic chemical shift reagent and a pool of proton analytes, allowing for effective diffusion of the proton analytes.
Another significant patent from Gruell is centered on chelating amphiphilic polymers. These amphiphilic polymers, characterized by the presence of chelating moieties, are structured as block copolymers that consist of both hydrophilic and hydrophobic blocks. Linked to the end-group of the hydrophilic block, these chelating moieties enable the polymers to self-assemble into micelles and polymersomes. They are suitable for various imaging techniques that require metal labeling, including MRI, SPECT, PET, or Spectral CT.
Career Highlights
Holger Gruell has developed his career at Koninklijke Philips Corporation N.V., a company renowned for its advancements in health technology. His work has contributed to the development of innovative solutions that improve patient outcomes in diagnostics and treatment.
Collaborations
During his tenure, Gruell collaborates with esteemed colleagues, including Sander Langereis and Rene Theodorus Wegh. Together, they work on interdisciplinary projects that aim to push the boundaries of current medical practices and technologies.
Conclusion
Holger Gruell stands out as an influential inventor in the medical technology field. With his nine patents that merge drug delivery and imaging, he continues to pave the way for innovative solutions that hold the potential to transform patient care. Through collaboration with his peers at Koninklijke Philips Corporation, Gruell is indeed making a significant impact on the future of healthcare technologies.