The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2017
Filed:
Sep. 03, 2009
Sander Langereis, Eindhoven, NL;
Jochen Keupp, Rosengarten, DE;
Holger Gruell, Eindhoven, NL;
Dirk Burdinski, Eindhoven, NL;
Danielle Beelen, Eindhoven, NL;
Sander Langereis, Eindhoven, NL;
Jochen Keupp, Rosengarten, DE;
Holger Gruell, Eindhoven, NL;
Dirk Burdinski, Eindhoven, NL;
Danielle Beelen, Eindhoven, NL;
Koninklijke Philips N.V., Eindhoven, NL;
Abstract
Described are drug carriers useful in magnetic resonance imaging (MRI)-guided drug release comprising a shell capable of releasing an enclosed biologically active agent as a result of a local stimulus, e.g. energy input, such as heat, wherein the shell encloses aF MR contrast agent. Preferably, the carrier also acts as a contrast enhancement agent for MRI based on the principle of Chemical Exchange-dependent Saturation Transfer (CEST). To this end the shell encloses a cavity that comprises a paramagnetic chemical shift reagent, a pool of proton analytes, and theF contrast agent, and wherein the shell allows diffusion of the proton analytes.