Hai Xing Chen

Title: Innovations of Hai Xing Chen

Introduction

Hai Xing Chen is a notable inventor based in Toronto, Canada. He has made significant contributions to the field of biotechnology, holding a total of nine patents. His work primarily focuses on methods for producing proteins in transgenic animals and advanced techniques for nucleic acid detection.

Latest Patents

One of his latest patents involves the production of human DNaseI in erythrocytes of transgenic non-human mammals using an erythroid-specific promoter. This method includes synthesizing an erythroid-specific globin gene promoter and globin gene locus control region. It also involves cloning the promoter and the globin gene locus control region along with a gene encoding a non-erythroid protein into a vector to obtain a transgene. The transgene is introduced into pronuclear embryos collected from a mammalian animal in vitro. These embryos are then transplanted into the oviduct of a female recipient, resulting in a transgenic animal that expresses the non-erythroid protein in progenitor cells of erythrocytes. Blood is collected from the transgenic animal to isolate the non-erythroid protein from the erythrocytes.

Another significant patent by Chen is a method of detecting nucleic acids with an amplified signal using nanoparticles. This method utilizes first and second amplification nanoparticles. It includes hybridizing segments of a target sequence with capture probes on capture particles and first amplification nanoparticles. The process forms a complex that allows for the detection of signals from reporter probes, enhancing the sensitivity of nucleic acid detection.

Career Highlights

Throughout his career, Hai Xing Chen has worked with various companies, including Acgt Medico Inc. His innovative approaches have led to advancements in biotechnology and molecular biology.

Collaborations

Chen has collaborated with notable individuals in his field, including Qiang Li and Muhammad Omair Noor. These collaborations have contributed to the development of his patented technologies.

Conclusion

Hai Xing Chen's contributions to biotechnology through his patents and collaborations highlight his role as a leading inventor in the field. His innovative methods for protein production and nucleic acid detection continue to influence research and development in biotechnology.