Location History:
- Bethesda, MD (US) (2019 - 2021)
- Rockville, MD (US) (1999 - 2022)
Company Filing History:
37 out of 3,539 
4 out of 3,923 
3 out of 2,104 
Years Active: 1999-2022
Areas of Expertise:
Title: George N. Pavlakis: A Leading Innovator in Biomedicine
Introduction
George N. Pavlakis, based in Rockville, MD, is a prominent inventor with a remarkable portfolio of 40 patents. His innovative work primarily focuses on the field of biomedicine, particularly in the development of therapeutic strategies that leverage interleukin-15 (IL-15) and novel nucleic acid vaccination techniques.
Latest Patents
Among his latest patents is the invention of codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells. This groundbreaking invention provides improved nucleic acids that enhance the expression of IL-15 in mammalian cells. The patent outlines methods for expressing IL-15 by transfecting cells with an optimized nucleic acid sequence, as well as providing expression vectors and IL-15 receptor alpha combinations that significantly increase IL-15 stability and potency in both in vitro and in vivo scenarios. Furthermore, Pavlakis has developed methods for altering immunodominance hierarchy using a DNA vaccine that expresses conserved regions of a virus, which can elicit broad immune responses through nucleic acid vaccines.
Career Highlights
Throughout his career, George N. Pavlakis has worked with esteemed organizations, including the United States of America as represented by the Secretary of the Department of Health and Human Services and Novartis AG. His contributions to the field have been recognized not just through his patents, but also through his commitment to advancing biotherapeutic innovations.
Collaborations
Pavlakis has collaborated with notable colleagues, including Barbara K. Felber and Antonio Valentin, enhancing the research and development process with their collective expertise. These collaborations have led to significant breakthroughs in immunology and therapeutic applications.
Conclusion
In summary, George N. Pavlakis is an influential inventor with a strong focus on biomedicine, evidenced by his extensive patent portfolio and impactful collaborations. His innovations, particularly in IL-15 therapies and immunization strategies, continue to contribute to advances in biomedical research and therapeutic applications.