George N Pavlakis

This inventor holds 41 USPTO granted patents and 10 published patent applications, plus 5 CIPO patents and 11 EPO patents, primarily in Immunotherapy Technologies. Top assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services, Novartis Ag, University of Washington. Active years: 1999-2026.

IDiyas Innovation Intelligence. (2026). Inventor Profile: George N Pavlakis. Retrieved from https://idiyas.com/inventor/george-n-pavlakis

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

USPTO Granted Patents = 41 (Patent Applications = 10)

% Patents Active = 87.8

CIPO Patents = 5

EPO Patents = 11 (Patent Applications = 12)

Average Co-Inventor Count = 2.3

ph-index = 14

Forward Citations = 649(Granted Patents)

Location History:

Bethesda, MD (US) (2019 - 2021)
Rockville, MD (US) (1999 - 2022)

Company Filing History:

38 out of 3,693

The United States of America, as Represented by the Secretary, Department of Health and Human Services

University of Washington

patents

4. 2 out of 1,217

The United States of America as Represented by the Department of Health

patents

5. 1 out of 2,202

The United States of America as Represented by the Secretary of

patents

where one patent can have more than one assignee

Years Active: 1999-2026

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Areas of Expertise:

IL-15

DNA Vaccine

Heterodimer

Thymic Output

Lymphopenia

Immunogenicity

mRNA Transport

Nucleic Acids

Expression Vectors

Fluorescent Proteins

Molecular Clones

Systemic Delivery

41 patents (USPTO):Sort by Forward CitationsExplore Patents

1. 12709635 - METHODS AND COMPOSITIONS FOR INDUCING AN IMMUNE RESPONSE USING CONSERVED ELEMENT CONSTRUCTS (2026-08-18),

2. 11339198 - Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells (2022-05-24),

3. 11167025 - Altering the immundominance hierarchy using a DNA vaccine expressing conserved regions (2021-11-09),

4. 11110150 - Complexes of IL-15 and IL-15Ralpha and uses thereof (2021-09-07),

5. 11041008 - Heterodimers of IL-15 and IL-15R alpha to increase thymic output and to treat lymphopenia (2021-06-22),

6. 10894816 - Use of IL-15 to increase thymic output and to treat lymphopenia (2021-01-19),

7. 10428133 - Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells (2019-10-01),

8. 10426830 - Altering the immundominance hierarchy using a DNA vaccine expressing conserved regions (2019-10-01),

9. 10335460 - IL-15 and IL-15Rα heterodimer dose escalation regimens for treating conditions (2019-07-02),

10. 10265382 - Complexes of IL-15 and IL-15Ralpha and uses thereof (2019-04-23),

11. 10093710 - Heterodimers of IL-15 and IL-15R alpha to increase thymic output and to treat lymphopenia (2018-10-09),

12. 9975937 - Heterodimers of IL-15 and IL-15R alpha to increase thymic output and to treat lymphopenia (2018-05-22),

13. 9931377 - Cell expressing complexes of IL-15 and IL-15Ralpha (2018-04-03),

14. 9790261 - Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells (2017-10-17),

15. 9725492 - Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells (2017-08-08),

Title: George N. Pavlakis: A Leading Innovator in Biomedicine

Introduction

George N. Pavlakis, based in Rockville, MD, is a prominent inventor with a remarkable portfolio of 40 patents. His innovative work primarily focuses on the field of biomedicine, particularly in the development of therapeutic strategies that leverage interleukin-15 (IL-15) and novel nucleic acid vaccination techniques.

Latest Patents

Among his latest patents is the invention of codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells. This groundbreaking invention provides improved nucleic acids that enhance the expression of IL-15 in mammalian cells. The patent outlines methods for expressing IL-15 by transfecting cells with an optimized nucleic acid sequence, as well as providing expression vectors and IL-15 receptor alpha combinations that significantly increase IL-15 stability and potency in both in vitro and in vivo scenarios. Furthermore, Pavlakis has developed methods for altering immunodominance hierarchy using a DNA vaccine that expresses conserved regions of a virus, which can elicit broad immune responses through nucleic acid vaccines.

Career Highlights

Throughout his career, George N. Pavlakis has worked with esteemed organizations, including the United States of America as represented by the Secretary of the Department of Health and Human Services and Novartis AG. His contributions to the field have been recognized not just through his patents, but also through his commitment to advancing biotherapeutic innovations.

Collaborations

Pavlakis has collaborated with notable colleagues, including Barbara K. Felber and Antonio Valentin, enhancing the research and development process with their collective expertise. These collaborations have led to significant breakthroughs in immunology and therapeutic applications.

Conclusion

In summary, George N. Pavlakis is an influential inventor with a strong focus on biomedicine, evidenced by his extensive patent portfolio and impactful collaborations. His innovations, particularly in IL-15 therapies and immunization strategies, continue to contribute to advances in biomedical research and therapeutic applications.

Profile summary based on public USPTO records.