The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 09, 2018
Filed:
Apr. 11, 2017
Applicant:
The United States of America As Represented BY the Secretary of the Department of Health and Human Services, Washington, DC (US);
Inventors:
George N. Pavlakis, Rockville, MD (US);
Barbara K. Felber, Rockville, MD (US);
Antonio Valentin, Frederick, MD (US);
Cristina Bergamaschi, Frederick, MD (US);
Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/62 (2006.01); C07K 14/54 (2006.01); C07K 14/715 (2006.01); C12N 15/09 (2006.01); A61K 38/00 (2006.01); C12N 5/07 (2010.01); C12P 21/02 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C07K 14/5443 (2013.01); C07K 14/7155 (2013.01); C12N 15/09 (2013.01); C12N 15/62 (2013.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01); C07K 2319/70 (2013.01); C12N 5/06 (2013.01); C12N 15/1138 (2013.01); C12P 21/02 (2013.01);
Abstract
The present invention provides method for promoting the maturation and export of T cells from thymic tissue by contacting the thymic tissue with supraphysiological levels of interleukin (IL)-15. The present invention also provides methods for preventing, alleviating, reducing, and/or inhibiting lymphopenia or peripheral depletion of lymphocytes in a patient in need thereof by administering to the patient IL-15.