The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 07, 2021

Filed:

Mar. 04, 2019
Applicants:

Novartis Ag, Basel, CH;

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);

Inventors:

Barbara K. Felber, Rockville, MD (US);

Sergio Finkielsztein, Newton, MA (US);

George N. Pavlakis, Bethesda, MD (US);

John V. Vournakis, Charleston, SC (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); A61K 38/20 (2006.01); A61K 39/00 (2006.01); A61K 38/17 (2006.01); A61K 35/13 (2015.01); A61K 47/36 (2006.01); C07K 16/24 (2006.01); C07K 16/28 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
A61K 38/2086 (2013.01); A61K 35/13 (2013.01); A61K 38/1793 (2013.01); A61K 39/0011 (2013.01); A61K 39/00114 (2018.08); A61K 47/36 (2013.01); C07K 16/244 (2013.01); C07K 16/2866 (2013.01); C12N 5/0686 (2013.01); C12N 15/85 (2013.01); A61K 2039/5152 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/55527 (2013.01); C07K 2317/24 (2013.01); C07K 2317/76 (2013.01); C12N 2500/90 (2013.01); C12N 2510/00 (2013.01);
Abstract

The present invention relates to agents that modulate interleukin-15 ('IL-15') signal transduction or function ('Therapeutic Agents') and the use ol” those agents to modulate immune function. The Therapeutic Agents target the interaction between IL-15 and its receptor and modulate IL-15-induced signal transduction. The Therapeutic Agents may be formulated with polymers, such as poly-β-1-♦4-N-acetylglucosamine. for administration to a human subject to modulate IL-15-mediated immune function.


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