The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 02, 2019
Filed:
Jul. 28, 2015
Novartis Ag, Basel, CH;
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);
Barbara K. Felber, Rockville, MD (US);
Sergio Finkielsztein, Newton, MA (US);
George N. Pavlakis, Bethesda, MD (US);
John N. Vournakis, Charleston, SC (US);
NOVARTIS AG, Basel, CH;
The United States of America Department of Health and Human Services, Washington, DC (US);
Abstract
Described herein are dose escalation regimens for the administration of complexes comprising interleukin-15 ('IL-15') covalently or noncovalently bound to IL-15 receptor alpha ('IL-15Rα') to patients in order to enhance IL-15-mediated immune function. In a specific aspect, the dose escalation regimens are useful in the prevention, treatment, and/or management of disorders in which enhancing IL-15-mediated function is beneficial, such as cancer, infectious diseases, immunodeficiencies and lymphopenia. In another specific aspect, the dose escalation regimens are useful for eradicating or reducing HIV in HIV-infected patients.