Armon R Sharei

Title: Armon R Sharei: Innovator in Microfluidic Delivery Systems

Introduction

Armon R Sharei is a prominent inventor based in Watertown, MA, known for his significant contributions to the field of microfluidics and cellular delivery systems. With a total of 17 patents to his name, Sharei has developed innovative methods that enhance the delivery of materials to various cell types, including red blood cells and immune cells. His work has the potential to impact medical research and therapeutic applications significantly.

Latest Patents

One of Sharei's latest patents focuses on the "Delivery of materials to anucleate cells." This invention includes methods, systems, articles, and techniques designed to deliver materials to anucleate cells, such as red blood cells. By utilizing a rapid deformation-based microfluidic system, Sharei has demonstrated the successful loading of red blood cells with macromolecules of varying sizes. This technique, previously incompatible with red blood cells due to their unique physical properties, has been refined to enable robust delivery through smaller constriction sizes and high speeds. The implications of this work extend to studying red blood cell diseases and utilizing red blood cells as a therapeutic platform.

Another notable patent is for the "Delivery of biomolecules to immune cells." This method and device allow for the preferential delivery of compounds, such as antigens, directly to the cytosol of immune cells. The process involves passing a cell suspension containing the target immune cell through a microfluidic device, where it is then contacted with the desired compound for delivery.

Career Highlights

Armon R Sharei has held positions at prestigious institutions, including the Massachusetts Institute of Technology (MIT) and Harvard College. His work at these institutions has allowed him to collaborate with leading researchers and contribute to groundbreaking advancements in the field of microfluidics.

Collaborations

Throughout his career, Sharei has worked alongside notable colleagues, including Klavs F Jensen and Robert Samuel Langer. These collaborations have further enriched his research and innovation efforts, leading to significant advancements in cellular delivery technologies.

Conclusion

Armon R Sharei's innovative work in microfluidic delivery systems has the potential to revolutionize how materials are delivered to cells, particularly in the fields of medical research and therapy. His contributions continue to pave the way for new applications and advancements in cellular biology.