The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 21, 2025
Filed:
May. 03, 2017
Stemcell Technologies Canada Inc., Vancouver, CA;
Jonathan B. Gilbert, Somerville, MA (US);
Bu Wang, Watertown, MA (US);
Scott Loughhead, Watertown, MA (US);
Howard Bernstein, Cambridge, MA (US);
Armon R. Sharei, Watertown, MA (US);
Finola Moore, Watertown, MA (US);
Stemcell Technologies Canada Inc., Vancouver, CA;
Abstract
The present invention provides methods for inducing tolerance and/or suppressing an immune response to an antigen by passing a cell suspension containing an anucleate cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell. In some embodiments, the anucleate cell is delivered to an individual and the antigen is delivered to and processed in a tolerogenic environment to induce tolerance and/or suppress an immune response to the antigen.