The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 07, 2021

Filed:

Oct. 30, 2015
Applicants:

Massachusetts Institute of Technology, Cambridge, MA (US);

President and Fellows of Harvard College, Cambridge, MA (US);

Inventors:

Armon R. Sharei, Watertown, MA (US);

Shirley Mao, Cambridge, MA (US);

George Hartoularos, Boston, MA (US);

Sophia Liu, Boston, MA (US);

Megan Heimann, Baltimore, MD (US);

Pamela Basto, Somerville, MA (US);

Gregory Szeto, Baltimore, MD (US);

Siddharth Jhunjhunwala, Bengaluru, IN;

Darrell Irvine, Arlington, MA (US);

Robert S. Langer, Newton, MA (US);

Klavs F. Jensen, Lexington, MA (US);

Ulrich H. Von Andrian, Chestnut Hill, MA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/42 (2006.01); C12M 3/06 (2006.01); A61K 39/00 (2006.01); A61K 45/06 (2006.01); A61K 49/00 (2006.01); C12N 15/87 (2006.01); G01N 33/50 (2006.01); C12N 5/0781 (2010.01); C12N 5/0783 (2010.01); C12N 5/0784 (2010.01);
U.S. Cl.
CPC ...
C12M 35/04 (2013.01); A61K 39/00 (2013.01); A61K 45/06 (2013.01); A61K 49/0017 (2013.01); C12M 23/16 (2013.01); C12M 35/00 (2013.01); C12N 5/0635 (2013.01); C12N 5/0636 (2013.01); C12N 5/0639 (2013.01); C12N 15/87 (2013.01); G01N 33/5047 (2013.01); A61K 2039/5158 (2013.01); C12N 2501/05 (2013.01); C12N 2501/998 (2013.01); C12N 2510/00 (2013.01); C12N 2527/00 (2013.01);
Abstract

A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.


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