The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2005
Filed:
Jan. 28, 2002
Toshio Ota, Tokyo, JP;
Takao Isogai, Ibaraki, JP;
Tetsuo Nishikawa, Tokyo, JP;
Koji Hayashi, Osaka, JP;
Kaoru Otsuka, Saitama, JP;
Jun-ichi Yamamoto, Chiba, JP;
Shizuko Ishii, Chiba, JP;
Tomoyasu Sugiyama, Tokyo, JP;
Ai Wakamatsu, Chiba, JP;
Keiichi Nagai, Tokyo, JP;
Tetsuji Otsuki, Chiba, JP;
Shin-ichi Funahashi, Ibaraki, JP;
Shoji Miyata, Kanagawa, JP;
Kenji Sobue, Ibaraki-shi, Osaka, 567-0812, JP;
Kenichiro Hayashi, Osaka, JP;
Toshio Ota, Tokyo, JP;
Takao Isogai, Ibaraki, JP;
Tetsuo Nishikawa, Tokyo, JP;
Koji Hayashi, Osaka, JP;
Kaoru Otsuka, Saitama, JP;
Jun-Ichi Yamamoto, Chiba, JP;
Shizuko Ishii, Chiba, JP;
Tomoyasu Sugiyama, Tokyo, JP;
Ai Wakamatsu, Chiba, JP;
Keiichi Nagai, Tokyo, JP;
Tetsuji Otsuki, Chiba, JP;
Shin-Ichi Funahashi, Ibaraki, JP;
Shoji Miyata, Kanagawa, JP;
Kenji Sobue, Ibaraki-shi, Osaka, 567-0812, JP;
Kenichiro Hayashi, Osaka, JP;
Other;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene 'C-NT2RP3001495' was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.