Location History:
- Kanagawa, JP (2006)
- Fujisawa, JP (2005 - 2007)
- Machida, JP (2006 - 2010)
- Tokyo, JP (2005 - 2012)
Company Filing History:
3 out of 949 
3 out of 730 
2 out of 940 
Years Active: 2005-2012
Title: The Innovations of Toshio Ota
Introduction
Toshio Ota is a prominent inventor based in Tokyo, Japan. He has made significant contributions to the field of biotechnology, particularly in the development of antibodies and proteins that play crucial roles in cellular differentiation and disease treatment. With a total of 13 patents to his name, Ota's work has the potential to impact various medical applications.
Latest Patents
One of Ota's latest patents involves an antibody directed to a protein that is essential for maintaining the differentiation of smooth muscle cells. This invention describes a cDNA fragment that was isolated using a culture system of chicken gizzard smooth muscle cells, employing differential display and subtracted hybridization methods. The resulting cDNA sequence led to the identification of a novel gene, 'C-NT2RP3001495', which encodes a protein with two WW domains that facilitate protein interactions. This protein is believed to regulate intracellular signal transduction and gene expression, making it valuable for developing drugs targeting diseases linked to smooth muscle cell differentiation abnormalities.
Another significant patent is the development of an anti-PERP antibody. This antibody specifically recognizes the three-dimensional structure of an extracellular region of a polypeptide encoded by the PERP gene. It has potential applications in treating diseases that exhibit high expression of this polypeptide. Additionally, the antibody can be utilized for diagnostic purposes, allowing for the detection of diseases related to PERP through immunological methods.
Career Highlights
Throughout his career, Toshio Ota has worked with notable companies, including Chugai Pharmaceutical Co., Ltd. His expertise in biotechnology and patent development has positioned him as a key figure in the industry.
Collaborations
Ota has collaborated with esteemed colleagues such as Takao Isogai and Tetsuo Nishikawa. Their combined efforts have contributed to advancements in the understanding and treatment of various medical conditions.
Conclusion
Toshio Ota's innovative work in biotechnology, particularly in the development of antibodies and proteins, showcases his significant contributions to medical science. His patents hold promise for advancing treatments for diseases related to smooth muscle cell differentiation and beyond.