Shizuko Ishii

Title: Shizuko Ishii: Innovator in Smooth Muscle Cell Research

Introduction

Shizuko Ishii is a prominent inventor based in Chiba, Japan. She has made significant contributions to the field of biotechnology, particularly in the study of smooth muscle cell differentiation. With a total of 7 patents to her name, her work has implications for drug development and understanding cellular processes.

Latest Patents

One of her latest patents involves an antibody directed to a protein that plays a crucial role in maintaining the differentiation of smooth muscle cells. This invention was developed through isolating a cDNA fragment using a culture system of chicken gizzard smooth muscle cells, employing differential display and subtracted hybridization methods. The resulting cDNA sequence led to the identification of a novel gene, 'C-NT2RP3001495', which encodes a protein with two WW domains that are essential for protein interactions. This protein is believed to regulate intracellular signal transduction and gene expression, making it vital for maintaining smooth muscle cell differentiation. Additionally, her patent titled "Heart20049410 full-length cDNA and polypeptides" provides novel full-length cDNAs derived from humans, which are useful for analyzing polypeptide functions.

Career Highlights

Throughout her career, Shizuko Ishii has worked with notable organizations, including the Research Association for Biotechnology and Chugai Pharmaceutical Co., Ltd. Her research has been instrumental in advancing our understanding of smooth muscle cell biology and its applications in medicine.

Collaborations

Shizuko has collaborated with esteemed colleagues such as Takao Isogai and Tomoyasu Sugiyama, contributing to a rich exchange of ideas and innovations in her field.

Conclusion

Shizuko Ishii's work exemplifies the impact of innovative research in biotechnology. Her patents and collaborations highlight her commitment to advancing scientific knowledge and developing potential therapeutic solutions.