Tomoyasu Sugiyama

Title: Innovative Contributions of Tomoyasu Sugiyama

Introduction

Tomoyasu Sugiyama, an accomplished inventor based in Tokyo, Japan, has significantly contributed to the field of biotechnology with a total of eight patents. His work primarily focuses on proteins involved in smooth muscle cell differentiation, which has implications for drug development in various diseases.

Latest Patents

Among his latest innovative patents is an antibody directed to a protein that plays a crucial role in maintaining the differentiation of smooth muscle cells. This invention arose from a meticulous process involving the isolation of a cDNA fragment through a culture system of chicken gizzard smooth muscle cells utilizing differential display and subtracted hybridization methods. By retrieving cDNA sequences from the Helix Research Institute (Japanese Patent Application No. 2000-118776), Sugiyama identified a novel gene named 'C-NT2RP3001495'. The protein encoded by this gene consists of two WW domains, which participate in protein interactions, suggesting its role in regulating intracellular signal transduction and gene expression. This discovery has pivotal applications in developing therapeutics targeting diseases associated with the abnormal maintenance of smooth muscle cell differentiation.

Another significant patent includes the provision of novel full-length cDNAs derived from humans. This patent outlines the determination of full-length nucleotide sequences and the corresponding amino acid sequences encoded by these sequences. The full-length nature of the cDNA includes the translation start site, providing valuable insights for analyzing the functions of the encoded polypeptide.

Career Highlights

Throughout his career, Sugiyama has worked with various organizations to enhance his research capabilities. Notable among them are the Research Association for Biotechnology and Chugai Seiyaku Kabushiki Kaisha, where he contributed his expertise in biotechnology.

Collaborations

Sugiyama has collaborated with distinguished colleagues, including Takao Isogai and Tetsuji Otsuki. These collaborations have enabled him to explore and expand the potential applications of his innovative discoveries in biotechnology.

Conclusion

Tomoyasu Sugiyama stands as a prominent figure in the realm of biotechnology, with a significant number of patents that demonstrate his dedication to advancing medical science. His innovative inventions, particularly in the area of smooth muscle cell differentiation, lay the groundwork for future therapeutic developments. As research continues, the impact of Sugiyama's work is likely to resonate within the fields of medicine and biotechnology for years to come.