Research Association for Biotechnology

Other

Chugai Seiyaku Kabushiki Kaisha

Acceleron Pharma Inc.

Tomoyasu Sugiyama

Takao Isogai

Keiichi Nagai

Ai Wakamatsu

Tetsuji Otsuki

Shizuko Ishii

Jun-Ichi Yamamoto

Kaoru Otsuka

Yasuhiko Masuho

Koji Hayashi

Hiroyuki Sato

Tetsuo Nishikawa

Toshio Ota

Yuri Hio

Ryotaro Irie

Kenji Nagahari

Yuuko Isono

Ichiro Tamechika

Naohiko Seki

Tsutomu Yoshikawa

Motoyuki Otsuka

Shin-Ichi Funahashi

Shoji Miyata

Kenji Sobue

Yuri Kawai

A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene 'C-NT2RP3001495' was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.

Antibody directed to protein involved in maintaining differentiation of smooth muscle cells

Novel full-length cDNAs are provided. cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.

Heart20049410 full-length cDNA and polypeptides

Genes associated with the maintenance of differentiation of smooth muscle cells

Novel full-length cDNAs are provided. 2443 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.

Full-length cDNA

Human cDNA encoding a secretory or membrane protein useful as a candidate for developing medicine or as a target molecule for developing medicine. The expression level of the polynucleotide of the present invention increased in NT2 cells after retinoic acid-treatment. Accordingly, this cDNA is associated neurological disease.

Secretory protein or membrane protein

Novel full-length cDNAs are provided. 1639 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.

Novel full-length cDNAs are provided. 1970 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.

Growing community of inventors

Tokyo, Japan

Tomoyasu Sugiyama