Company Filing History:
Years Active: 2016-2024
Title: Zhitong Liu: Innovator in DNA Sequencing Technologies
Introduction
Zhitong Liu is a prominent inventor based in Foster City, California, known for his significant contributions to the field of DNA sequencing technologies. With a total of six patents to his name, Liu has been at the forefront of innovations that enhance the accuracy and efficiency of massive parallel sequencing.
Latest Patents
Liu's latest patents include groundbreaking methods and compositions aimed at reducing base errors in massive parallel sequencing through a technique known as Triseq sequencing. This method involves ligating a UMI adapter, amplifying DNA fragments with dUTP, and enriching target molecules using a combination of forward and reverse primers. The process also includes the removal of dU-containing template DNA, organizing the DNA into primary clones and subclones, and labeling them with unique molecular identifiers (UMIs). Additionally, Liu has developed methods for amplifying DNA and generating highly sensitive sequencing results from target-enriched DNA molecules, referred to as SubDivision-Seq. This innovative approach also consists of two parts, focusing on creating a target-enriched DNA library and deducing consensus sequences from subclones and primary clones.
Career Highlights
Zhitong Liu is currently employed at Paragon Genomics, Inc., where he continues to push the boundaries of DNA sequencing technology. His work has been instrumental in advancing the capabilities of next-generation sequencing, making it more reliable and efficient for various applications in genomics.
Collaborations
Liu collaborates with notable colleagues, including Guoying Liu and David Debruyne, who contribute to the innovative environment at Paragon Genomics, Inc. Their combined expertise fosters a culture of creativity and scientific advancement.
Conclusion
Zhitong Liu's contributions to DNA sequencing technologies exemplify the impact of innovation in the field of genomics. His patents and ongoing work at Paragon Genomics, Inc. highlight the importance of advancing scientific methods to improve accuracy and efficiency in genetic research.