Location History:
- Houston, TX (US) (2002 - 2008)
- Galveston, TX (US) (2000 - 2009)
Company Filing History:
Years Active: 2000-2009
Title: Xue-Jie Yu: Innovator in Immunology
Introduction
Xue-Jie Yu is a prominent inventor based in Galveston, TX (US). She has made significant contributions to the field of immunology, particularly through her research on outer membrane proteins. With a total of 10 patents, her work has implications for vaccine development and disease diagnostics.
Latest Patents
Among her latest patents, Xue-Jie Yu has focused on the 28-kDa outer membrane proteins (P28) encoded by a multigene family. This family consists of 21 members located in a 23-kb DNA fragment within the genome. Fifteen of these proteins are claimed as novel sequences, showcasing a 20-83% amino acid sequence identity among various P28 proteins. Her research indicates that six of the ten tested P28 genes were actively transcribed in cell cultures, suggesting their role as active genes encoding polymorphic forms of the P28 proteins. The antigenic diversity of the P28 proteins among different isolates suggests their potential involvement in immune avoidance.
Another significant patent involves the cloning, sequencing, and expression of homologous immunoreactive 28-kDa protein genes, including p28-1, -2, -3, -5, -6, -7, and -9. This multigene locus encodes all nine homologous 28-kDa protein genes. The recombinant 28-kDa proteins have shown reactivity with convalescent phase antiserum from an infected dog, indicating their potential utility in developing effective vaccines and serodiagnostics.
Career Highlights
Xue-Jie Yu is affiliated with the Research Development Foundation, where she continues her innovative work in immunology. Her research has garnered attention for its potential applications in public health and disease prevention.
Collaborations
Xue-Jie Yu has collaborated with notable colleagues, including David H. Walker and Jere W. McBride. These collaborations have further enriched her research and expanded the impact of her inventions.
Conclusion
Xue-Jie Yu's contributions to immunology through her patents and research are paving the way for advancements in vaccine development and disease diagnostics. Her innovative work continues to influence the field significantly.