Location History:
- Longmont, CO (US) (1997 - 2001)
- Boulder, CO (US) (1997 - 2008)
Company Filing History:
4 out of 7 
4 out of 131 
4 out of 1,289 
Years Active: 1997-2008
Title: The Innovative Mind of Wolfgang A. Pieken: A Look into His Contributions
Introduction
Wolfgang A. Pieken, an esteemed inventor based in Longmont, Colorado, has made significant contributions to the field of molecular biology through his innovative inventions. With a portfolio encompassing 14 patents, Pieken has been at the forefront of developing novel methodologies for the synthesis and purification of oligonucleotides and their applications.
Latest Patents
Among his latest patents, Pieken's work includes a groundbreaking method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method. This invention details a novel approach for immobilizing biomolecules onto a support. It focuses on the use of cycloaddition reactions, specifically the Diels-Alder reaction, to achieve this immobilization. The invention also introduces novel immobilized biomolecules that can be derived from this method.
Another notable patent features methods for the integrated synthesis and purification of oligonucleotides. This innovation discloses methods utilizing capping reagents with dual functional groups. The first functional group enhances the capping process, while the second functions as a chemical purification handle to effectively trap truncated oligonucleotides during the solid-phase synthesis, allowing for the generation of pure full-length products. This method, too, employs cycloaddition reactions as a pivotal mechanism, significantly improving the efficiency of the oligonucleotide development process.
Career Highlights
Pieken has contributed his expertise to various reputable organizations, including Nexstar Pharmaceuticals, Inc. and Proligo, LLC. His work in these companies has reinforced his standing as a leading figure in the development of oligonucleotide technologies.
Collaborations
Throughout his career, Pieken has had the opportunity to collaborate with esteemed colleagues, such as Larry M. Gold and Fritz Eckstein. These partnerships have further facilitated innovation and knowledge exchange, reinforcing the impact of their collective work in the field.
Conclusion
Wolfgang A. Pieken exemplifies the essence of innovation in biotechnology. His significant contributions, encapsulated in his numerous patents, have paved the way for advancements in the synthesis and application of oligonucleotides. His continued work promises to further enhance the capabilities of molecular biology, demonstrating the vital role of inventors in shaping the future of scientific research.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.