The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 16, 1997
Filed:
May. 04, 1995
Applicant:
Inventors:
Fritz Eckstein, Gottingen, DE;
Wolfgang Pieken, Boulder, CO (US);
Fritz Benseler, Gleichen/Etzborn, DE;
David B Olsen, West Point, PA (US);
David M Williams, Cherry Hinton, GB;
Olaf Heindenreich, Gottingen, DE;
Assignee:
Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V., Gottingen, DE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07H / ; C07H / ; C12P / ;
U.S. Cl.
CPC ...
536 253 ; 536 231 ; 536 245 ; 435 911 ;
Abstract
The present invention refers to an RNA molecule with catalytic activity comprising at least one modified nucleoside, wherein the hydroxy group at the 2'-position of the fibose sugar is replaced by a modifier group, selected from halo, sulfhydryl, azido, amino, monosubstituted amino, and disubstituted andno groups, a process for the preparation of modified KNA molecules and the use of modified KNA molecules as therapeutic agents and biocatalysts.