The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2004
Filed:
Jul. 08, 1999
Applicant:
Inventors:
Wolfgang Pieken, Boulder, CO (US);
Ken Hill, Nederland, CO (US);
Bruce Eaton, Boulder, CO (US);
Danny McGee, San Mateo, CA (US);
Kurt Vagle, Longmont, CO (US);
Larry Gold, Boulder, CO (US);
Andrew Stephens, Boulder, CO (US);
Assignee:
Proligo, LLC, Boulder, CO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 ; C07H 2/102 ; C07H 1/900 ;
U.S. Cl.
CPC ...
C12Q 1/68 ; C07H 2/102 ; C07H 1/900 ;
Abstract
This invention discloses a novel method for conjugating macromolecules to other molecular entities. Specifically, this invention discloses a method for conjugating or derivatizing macromolecules, such as oligonucleotides and proteins, using cycloaddition reactions, such as the Diels-Alder reaction or 1,3-dipolar cycloadditions. Included in the invention are the novel bioconjugated macromolecules that can be prepared according to the method of the invention.